Silencing the intestinal GUCY2C tumor suppressor axis requires APC loss of heterozygosity
نویسندگان
چکیده
منابع مشابه
Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.
Allelic deletions of tumor suppressor genes have been observed frequently in a variety of human tumors. These losses are believed to contribute to the development of human cancer. Three of the most frequently deleted chromosomal loci contain the tumor suppressor genes p53, retinoblastoma (Rb), and mcc/apc. In order to detect loss of heterozygosity (LOH) within these genes in dysplastic and canc...
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Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression. In this study, we explor...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2020
ISSN: 1538-4047,1555-8576
DOI: 10.1080/15384047.2020.1779005